Organometallic Compounds
Medchemexpress LLC 1-phenyl-2,5,8,11,14-pentaoxahexadecan-16-ol | 57671-28-0 | MFCD06797154 | 98.6% | 328.40 g/mol | C17H28O6 | 1 G
BnO-PEG5-OH is a benzyl-terminated PEG5 primary alcohol used as a flexible linker in PROTAC synthesis. It provides a short polyethylene glycol spacer with a terminal benzyl-protected alcohol functionality that can be modified for conjugation to ligands and linkers.
- Provides a PEG5 spacer for flexibility and improved solubility.
- Benzyl-protected terminal alcohol enables selective deprotection and further functionalization.
- High purity suitable for medicinal chemistry and research use.
- Characterized by certificate of analysis, 1H NMR, and RP-HPLC documentation.
- Available in small pack sizes for synthetic applications.
![Medchemexpress LLC [2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid | 1648843-04-2 | 98.7% | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233653.png-250.jpg)
Medchemexpress LLC [2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid | 1648843-04-2 | 98.7% | 1 ML
SX-682 is a small-molecule allosteric inhibitor of chemokine receptors CXCR1 and CXCR2. It has been investigated preclinically and in clinical trials for reducing tumor myeloid-derived suppressor cell recruitment and enhancing anti-tumor immune responses.
- Potent CXCR1/2 allosteric inhibitor used in research.
- Investigated in immuno-oncology and tumor microenvironment studies.
- Reported to reduce myeloid-derived suppressor cell recruitment.
- Supplied for laboratory research, often as concentrated solutions or milligram-scale powders.
- Soluble in DMSO at high concentrations for in vitro use.
Medchemexpress LLC HO-PEG3-(CH2)6-Cl | 1355955-95-1 | 95.0% | 268.78 | C12H25ClO4 | 5 MG
HO-PEG3-(CH2)6-Cl is a PEG-based PROTAC linker containing a hydroxy-terminated PEG3 spacer attached to a six-carbon chain bearing a terminal chloride. It is intended as a functionalized spacer for assembling PROTACs and other ligand-linker conjugates and is supplied for research use only.
- Hydroxy-terminated PEG3 linker for flexible spacer design.
- Six-carbon chloroalkyl handle enables haloalkane conjugation chemistry.
- Suitable for assembling PROTACs and ligand-linker constructs.
- Available in small research-scale quantities, such as 5 mg.
- Molecular formula C12H25ClO4 and molecular weight 268.78.
- For research use only; not for human or clinical use.
Medchemexpress LLC 4,7,10-trioxa-3-siladodecan-12-ol, 2,2,3,3-tetramethyl- | 201037-95-8 | MFCD30471718 | ≥98.0% | 264.43 g/mol | C12H28O4Si | 250 MG
TBDMS-PEG3-OH is a tert-butyldimethylsilyl (TBDMS)-protected PEG3 alcohol used as a linker or spacer in organic synthesis, PROTAC construction, and drug-delivery conjugation. It provides a protected terminal alcohol for selective deprotection and coupling reactions.
- Provides a TBDMS-protected terminal alcohol for selective deprotection and coupling.
- Suitable as a PEG3 linker or spacer in medicinal chemistry and PROTAC synthesis.
- High purity (≥98%) and molecular weight 264.43 g/mol.
- Liquid, colorless to light yellow, convenient for solution-phase reactions.
- Recommended storage: pure form -20°C (long term) or 4°C (short term); in solvent store at -80°C.
Medchemexpress LLC 2-(2-(2-Bromoethoxy)ethoxy)ethyl methanesulfonate | 2702323-73-5 | 95.0% | 291.16 | 100 MG
Br-PEG3-MS is a PEG-based PROTAC linker employed in the synthesis of PROTACs. These molecules feature two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein. PROTACs leverage the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Azido-PEG3-SS-PEG3-azide | 1310827-27-0 | 99.3% | 468.59 | 50 MG
Azido-PEG3-SS-PEG3-azide is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs themselves are agents that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- A PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Contains an Azide group.
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Alkyne-containing molecules.
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing molecules.
Medchemexpress LLC Mal-amido-PEG3-acid | 2055353-75-6 | 98% | 372.37 | 100 MG
Mal-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N3-peg3-ch2ch2-boc | 252881-73-5 | MFCD22201543 | ≥98.0% | 303.35 g/mol | C13H25N3O5 | 1 G
N3-PEG3-CH2CH2-Boc is an azide-functionalized, Boc-protected PEG3 cleavable linker used for bioconjugation and click chemistry applications such as ADC and PROTAC synthesis.
- Azide functional group enables CuAAC and SPAAC click reactions.
- Boc-protected terminus allows orthogonal deprotection strategies.
- Three-unit PEG spacer improves solubility and flexibility in conjugates.
- High purity suitable for synthesis and analytical workflows.
- Available in multiple packaging sizes for lab-scale use.
Medchemexpress LLC m-PEG3-Aminooxy | 248275-10-7 | 98.0% | C7H17NO4 | 500 MG
m-PEG3-Aminooxy is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs consist of two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other the target protein. They leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Used as a PEG-based PROTAC linker
- Facilitates the synthesis of PROTACs
- Involves two ligands connected by a linker
- Utilizes the ubiquitin-proteasome system
- Enables selective degradation of target proteins
Medchemexpress LLC Mal-amido-PEG3-acid | 2055353-75-6 | 372.37 | 50 MG
Mal-amido-PEG3-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system, selectively degrading target proteins by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker.
- PEG-based linker
- Used in PROTAC synthesis
- Exploits ubiquitin-proteasome system
- Facilitates selective degradation of target proteins
Medchemexpress LLC Mal-amido-PEG3-acid | 2055353-75-6 | 372.37 | 250 MG
Mal-amido-PEG3-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs, which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only and has not been fully validated for medical applications.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits ubiquitin-proteasome system
- For research use only
Medchemexpress LLC M-PEG3-OMs | 74654-05-0 | C8H18O6S | 1 G
m-PEG3-OMs is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins